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by MS Zaazouee 2024 Cited by 2Propofol is the most commonly used intravenous anesthetic medication for induction and maintenance of anesthesia due to its quick onset and Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or Notes ; DRUG NAME, ondansetron (Zofran), metoclopramide (Reglan) ; CLASS, 5-HT3 receptor antagonist, D2 dopamine receptor antagonist ; MECHANISM OF ACTION %PDF-1.5 % 1 0 obj endobj 2 0 obj stream application/pdf David Wells Adobe PDF Library 10.0; modified using iText 5.1.3 1T3XT BVBA T- T- Acrobat PDFMaker 10.1 for Word endstream endobj 3 0 obj endobj 5 0 obj endobj 6 0 obj endobj 4 0 obj endobj 64 0 obj [7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 Includes Ondansetron indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. These include ondansetron, granisetron, dolasetron, and palonosetron. The mechanism of action is to block serotonin from interacting with the 5-HT3 receptor. Of these, ondansetron and granisetron are the most frequently encountered. Intravenous (IV) and oral (PO) preparations are available. Side effects include headache, dizziness, and
Save on your favourite brands online. Enjoy free shipping on orders $50 or click collect in-store. Join Sister Club and get exclusive gifts more. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy.It is typically used after other antinausea drugs have failed. [17]A large multi-center cohort study found no association between ondansetron exposure and fetal risk compared to other antiemetic drugs. Smelling peppermint oil at the onset of nausea may help reduce your symptoms. Ginger-Mechanism of action in chemotherapy-induced nausea and Onset of action up to 30 minutes; Pharmacology Review. Indications Administer IV Ondansetron slowly over 2 minutes (neat or diluted) to prevent blurred vision and exofresh tablet Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. The half-life of ondansetron after either an 8 mg oral dose or intravenous dose was approximately 3-4 hours and could be extended to 6-8 hours in the elderly.
Ondansetron may be taken up to 3 times a day for 1 to 2 days after each chemotherapy or radiation treatment. If you are taking this medication on a prescribed schedule, take it Item Name- Onset Details: First line treatment for patients with For special antiemetric action. Special Condition Needs Special Antiemetic Onset and duration of action f. Half-life g. Side effects. 4. List the indications and contraindications of ondansetron (Zofran) ODT. a. Indications b Mechanism of Action: Ondansetron selectively antagonises 5-HT3-receptor on Onset: Approx 30 minutes. Pharmacokinetics: Absorption: Passively and B12, but it has rapid onset of action and provides prolonged effect for a month or more. R-Ondansetron (As Hcl. Dihydrate) (1mg/ml) injection ondansetron turnover, CYP3A4 played the predominant role. Because of the multiplicity of metabolic enzymes capable of metabolizing ondansetron, it is likely that inhibition or loss of one enzyme (e.g, CYP2D6 genetic deficiency) will be compensated by others and may result in little change in overall rates of ondansetron elimination. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT3 type are. Adults: Approximately 3–3.5 hours after single 8-mg oral dose; approximately 4 hours after IV administration. Children and adolescents 3–18
